Design of genetic circuits that are robust to resource competition

The ability to engineer genetic circuits in living cells has tremendous potential many applications, from health, energy, bio-manufacturing. Although substantial efforts have gone into design approaches that make robust variable cellular context, context dependence of remains a significant hurdle. We review intra-cellular resource competition, one culprit dependence, and summarize recent toward mitigate it. classify these two main groups: global control local control. In the former, pool resources is regulated meet demand, latter, individual modules are be variability resources. Within each group, we highlight both feedback feedforward implementations.